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What is the importance of Magnesium?

Magnesium is present in all cells of the body and is involved in over 300 enzymatic processes, including energy production. Magnesium is essential for maintaining normal bone density, normal cardiac rhythmicity, healthy heart function, and normal blood glucose regulation.

Magnesium is one of the most common worldwide deficiencies, and it plays a role in most of the common health struggles people face every day. Magnesium is a basic element of life, much like water and air. We need a lot of magnesium, roughly 1000 mg/day, for a healthy, active individual to keep up with the demands of the body. Magnesium is to the body like oil is to a car’s engine, and if we are deficient, problems will arise.

How does Magnesium affect detoxification?

Without sufficient magnesium, the body struggles to make and utilize protein and enzymes. It is also unable to properly methylate and detoxify and/or process and utilize anti-oxidants like vitamins C and E.

Magnesium is extremely critical for proper detoxification processes. As our world has gotten increasingly more toxic, our need for magnesium has increased.

What is the importance of Brain Calm Magnesium?

We developed Brain Calm Magnesium in order to provide the best form of magnesium to improve brain function and neuronal health. This product helps you to focus, concentrate, and perform at a significantly higher level. In addition, it is fantastic for assisting with anxiety, while improving mood, memory, and sleep.

Boosting the brain’s magnesium level is vital to healthy cognition, which includes long- and short-term memory, learning, stress management, and sleep.

What is Bioavailable Magnesium?

Because many forms of magnesium have low bioavailability, we carefully selected magnesium compounds backed by research and studies to formulate Brain Calm Magnesium. This product features a unique combination of highly absorbable, organic Albion minerals—di-magnesium malate and magnesium lysinate glycinate chelate—and Magtein.

Magtein is a groundbreaking organic magnesium compound that was developed by MIT (Massachusetts Institute of Technology) researchers to support “brain power.”

What is Magtein-Patented Magnesium L-Threonate?

Magtein is the result of 10 years of research at MIT. This novel form of magnesium is changing the way we support brain health. Unlike other brain products on the market that work via brain stimulation (often overstimulation), Magtein works via a completely different mechanism.

When brain magnesium levels are not optimal, synapse function deteriorates. By delivering magnesium into synapses, Magtein helped brain cells stay healthy without being overactivated; consequently, brain cells respond to signals with clarity and robustness.

Why is Magtein important for our brain Magnesium levels?

Studies show that Magtein crosses the blood-brain barrier and raises the brain’s magnesium levels, which results in increased magnesium deposits in neural synapses, increased neural synaptic density, and improved brain function.[2.4]

One animal study showed that when the bioavailability of several magnesium compounds was compared to controls, only Magtein significantly enhanced magnesium bioavailability and produced a significant increase (7% to 15%) in rat cerebrospinal fluid.[2] These small but significant increases in brain magnesium levels produced profound effects on neurological function.

How does Magtein support healthy synaptic numbers and functions?

Maintaining extracellular magnesium in the brain helps preserve synaptic density and keeps the synapses working properly.[2,5] By increasing magnesium concentration in the extracellular fluid, researchers observed permanent enhancement of synaptic plasticity in networks of cultured hippocampal neurons.[5]

Delving deeper into the mechanisms involved, later animal research showed that magnesium increased receptor signaling; specifically, the signaling of the NR2B-containing N-methyl-D-aspartate (NMDA) receptor. NMDA receptors are rich in the hippocampus and play a pivotal role in memory processes.

Data from these studies suggest that increasing brain magnesium with Magtein “enhances both short-term synaptic facilitation and long-term potentiation and thereby supports synaptic plasticity and learning and memory functions in rats.”[2,3,6]

How does Magtein support cognitive health?

The benefits of Magtein were observed in several pre-clinical animal studies that used assessments, such as the NORT (novel object recognition test), T-maze, Morris water maze, conditioned fear memory, and conditioned taste aversion.

In these studies, researchers demonstrated that when brain magnesium levels were increased, significant benefits were detected in multiple aspects of learning and memory in young and aged rodents.[2,4,7]

For instance, NORT tests performed by Slutsky et al revealed ≈135% improvement in short-term memory and ≈85% improvement in long-term memory of aged rats treated with Magtein as compared to control (untreated) rats.

One study examined the effects of Magtein in test mice (genetically altered mice that model age-related cognitive changes). Li et al found that the test mice not given Magtein exhibited “unequivocal learning deficits,” while the test mice given Magtein performed similarly to normal mice.[3]

In short, Magtein helped preserve normal brain function. When magnesium levels in the brain tissue were quantified, the relationship became even clearer: According to researchers, brain magnesium levels positively correlated with cognitive function; that is, the lower a mouse’s brain magnesium level, the poorer its memory function in the NORT task.

Furthermore, histological analysis of brain tissue showed that Magtein administration preserved synapse density and NMDA receptor signaling and also had positive effects on the expression of certain proteins associated with changes in memory.*[3]

A large-scale human clinical trial has recently been completed. The results, publication forthcoming, support the in vitro and animal findings that Magtein positively affects memory, cognition, and synapse density.

How does Magnesium affect stress management, sleep quality and mood?

Magnesium is known to benefit the body in ways that counter stress, promote restful sleep, and support a healthy mood. In rats, magnesium administration attenuated neurologic changes brought on by chronic mild stress.[8]

Additionally, by increasing fear memory extinction, Magtein showed promise as a modulator of worry.[4,9] In human studies, magnesium supplementation partially reversed sleep changes associated with aging and improved objective and subjective measures of sleep.[10,12]

Improving sleep quality and countering the effects of chronic stress can positively impact mood— another area that is beneficially influenced by optimal magnesium status. (8,9,13,14)

How does Dr. Jockers use this product?

I use Brain Calm Magnesium on a daily basis, myself, during the daytime in order to improve my concentration and productivity. I also take some at night and have noticed much deeper and more restorative sleeping patterns.

I use this product with clients who are struggling with memory, anxiety, sleep, and mood issues.

What is the recommended dosage?

Normal Dosage:  1 cap – 3x daily with or without food

Advanced Dosage:  2 caps – 3x daily with or without food