Brain Calm Magnesium
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The Importance of Magnesium:
Magnesium is present in all cells of the body and is involved in over 300 enzymatic processes, including energy production. Magnesium is essential for maintaining normal bone density, normal cardiac rhythmicity, normal pulmonary function, and normal blood glucose regulation.
Magnesium is one of the most common world-wide deficiencies and it plays a role in most of the common health struggles people face every day.  Magnesium is a basic element of life much like water and air. We need a lot of magnesium, roughly 1000 mgs/day for a healthy active individual to keep up with the demands of the body. Magnesium is to the body like oil is to a car’s engine and if we are deficient problems will arise.
Magnesium and Detoxification:
Without sufficient magnesium the body struggles to make and utilize protein and enzymes. It is also unable to properly methylate and detoxify and/or process and utilize anti-oxidants like vitamin C and E.
Magnesium is extremely critical for proper detoxification processes. As our world has gotten increasingly more toxic, our need for magnesium has increased. Meanwhile, the nutrition of our modern food has increasingly been diminished. This is due to over-cropping, poor composting and pesticides/herbicide chemical residue which reduces nutritional quality of the soil and produce.
Introducing Brain Calm Magnesium:
We developed Brain Calm Magnesium in order to provide the best form of magnesium to improve brain function and neuronal health. This product helps you to focus, concentrate and perform at a significantly higher level. In addition, it is fantastic for reducing anxiety, while improving mood, memory and sleep.
Brain Calm Magnesium features key Albion forms of Magnesium (malate, lysinate & glycinate chelate) as well as magnesium L-threonate the only form of magnesium proven in animal studies to cross the blood-brain barrier. Boosting the brain’s magnesium level is vital to healthy cognition, which includes long- and short-term memory, learning, stress management and sleep.
Because many forms of magnesium have low bioavailability, we carefully selected magnesium compounds backed by research and studies to formulate Brain Calm Magnesium. This product features a unique combination of highly absorbable, organic Albion minerals—di-magnesium malate and magnesium lysinate glycinate chelate—and Magtein.
Magtein is a groundbreaking organic magnesium compound that was developed by MIT (Massachusetts Institute of Technology) researchers to support “brain power.”
Magtein – Patented Magnesium L-Threonate
Magtein is the result of 10 years of research at MIT. This novel form of magnesium is changing the way we support brain health. Unlike other brain products on the market that work via brain stimulation (often overstimulation), Magtein works via a completely different mechanism.
When brain magnesium levels are not optimal, synapse function deteriorates. By delivering magnesium into synapses, Magtein helps brain cells stay healthy, without being overactivated; consequently, brain cells respond to signals with clarity and robustness.*
Magtein Raises Brain Magnesium Levels
Studies show that Magtein crosses the blood-brain barrier and raises the brain’s magnesium levels, which result in increased magnesium deposits in neural synapses, increased neural synaptic density, and improved brain function.[2.4]
One animal study showed that when the bioavailability of several magnesium compounds was compared to controls, only Magtein significantly enhanced magnesium bioavailability and produced a significant increase (7% to 15%) in rat cerebrospinal fluid. These small but significant increases in brain magnesium levels produced profound effects on neurological function.
Magtein Supports Healthy Synaptic Number and Function
Maintaining extracellular magnesium in the brain helps preserve synaptic density and keeps the synapses working properly.[2,5] By increasing magnesium concentration in the extracellular fluid, researchers observed permanent enhancement of synaptic plasticity in networks of cultured hippocampal neurons.
Delving deeper into the mechanisms involved, later animal research showed that magnesium increased receptor signaling; specifically, the signaling of the NR2B-containing N-methyl-D-aspartate (NMDA) receptor. NMDA receptors are rich in the hippocampus and play a pivotal role in memory processes.
Data from these studies suggest that increasing brain magnesium with Magtein “enhances both short-term synaptic facilitation and long-term potentiation and thereby supports synaptic plasticity and learning and memory functions in rats.”[2,3,6]
Magtein Supports Cognitive Health
The benefits of Magtein were observed in several pre-clinical animal studies that used assessments, such as the NORT (novel object recognition test), T-maze, Morris water maze, conditioned fear memory, and conditioned taste aversion.
In these studies, researchers demonstrated that when brain magnesium levels were increased, significant benefits were detected in multiple aspects of learning and memory in young and aged rodents.[2,4,7]
For instance, NORT tests performed by Slutsky et al revealed ≈135% improvement in short-term memory and ≈85% improvement in long-term memory of aged rats treated with Magtein as compared to control (untreated) rats.
One study examined the effects of Magtein in test mice (genetically altered mice that model age-related cognitive changes). Li et al found that the test mice not given Magtein exhibited “unequivocal learning deficits,” while the test mice given Magtein performed similarly to normal mice.
In short, Magtein helped preserve normal brain function. When magnesium levels in the brain tissue were quantified, the relationship became even clearer: According to researchers, brain magnesium levels positively correlated with cognitive function; that is, the lower a mouse’s brain magnesium level, the poorer its memory function in the NORT task.
Furthermore, histological analysis of brain tissue showed that Magtein administration preserved synapse density and NMDA receptor signaling and also had positive effects on the expression of certain proteins associated with changes in memory.*
A large-scale human clinical trial has recently been completed. The results, publication forthcoming, support the in vitro and animal findings that Magtein positively affects memory, cognition, and synapse density.
Magnesium in Stress Management, Sleep Quality, and Mood
Magnesium is known to benefit the body in ways that counter stress, promote restful sleep, and support a healthy mood. In rats, magnesium administration attenuated neurologic changes brought on by chronic mild stress.
Additionally, by increasing fear memory extinction, Magtein showed promise as a modulator of worry.[4,9] In human studies, magnesium supplementation partially reversed sleep changes associated with aging and improved objective and subjective measures of sleep.[10,12]
How I Use This Product:
I use Brain Calm Magnesium on a daily basis myself during the daytime in order to improve my concentration and productivity. I also take some at night and have noticed much deeper and more restorative sleeping patterns.
I use this product with clients that are struggling with memory, anxiety, sleep, mood issues and depression. I also use it for individuals with neurodegenerative issues such as dementia, Alzheimer’s and Parkinson’s.
- Moshfegh AJ, Goldman JD, Ahuja JK, et al. U.S. Department of Agriculture, Agricultural Research Service. What we eat in America, Nhanes 2005-2006. Usual nutrient intakes from food and water compared to 1997 dietary reference intakes for vitamin D, calcium, phosphorus, and magnesium. http://www.ars.usda.gov/ SP2UserFiles/Place/80400530/pdf/0506/usual_nutrient_intake_vitD_ca_phos_ mg_2005-06.pdf. Published July 2009. Accessed November 21, 2014.
- Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010 Jan 28;65(2):165-77. [PMID: 20152124]
- Li W, Yu J, Liu Y, et al. Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer’s disease mouse model. Mol Brain. 2014 Sep 13;7(1):65. [PMID: 25213836]
- Abumaria N, Yin B, Zhang L, et al. Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala. J Neurosci. 2011 Oct 19;31(42):14871-81. [PMID: 22016520]
- Slutsky I, Sadeghpour S, Li B, et al. Enhancement of synaptic plasticity through chronically reduced Ca2+ flux during uncorrelated activity. Neuron. 2004 Dec 2;44(5):835-49. [PMID: 15572114]
- Wang D, Jacobs SA, Tsien JZ. Targeting the NMDA receptor subunit NR2B for treating or preventing age-related memory decline. Expert Opin Ther Targets. 2014 Oct;18(10):1121-30. [PMID: 25152202]
- Mickley GA, Hoxha N, Luchsinger JL, et al. Chronic dietary magnesium-Lthreonate speeds extinction and reduces spontaneous recovery of a conditioned taste aversion. Pharmacol Biochem Behav. 2013 May;106:16-26. [PMID: 23474371]
- Pochwat B, Szewczyk B, Sowa-Kucma M, et al. Antidepressant-like activity of magnesium in the chronic mild stress model in rats: alterations in the NMDA receptor subunits. Int J Neuropsychopharmacol. 2014 Mar;17(3):393-405. [PMID: 24067405]
- Abumaria N, Luo L, Ahn M, et al. Magnesium supplement enhances spatial-context pattern separation and prevents fear overgeneralization. Behav Pharmacol. 2013 Aug;24(4):255-63. [PMID: 23764903]
- Held K, Antonijevic IA, Künzel H, et al. Oral Mg(2+) supplementation reverses agerelated neuroendocrine and sleep EEG changes in humans. Pharmacopsychiatry. 2002 Jul;35(4):135-43. [PMID: 12163983]
- Abbasi B, Kimiagar M, Sadeghniiat K, et al. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 201 Dec;17(12):1161-69. [PMID: 23853635].
- Hornyak M, Voderholzer U, Hohagen F, et al. Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. Sleep. 1998 Aug 1;21(5):501-05. [PMID: 9703590]
- Fromm L, Heath DL, Vink R, et al. Magnesium attenuates post-traumatic depression/anxiety following diffuse traumatic brain injury in rats. J Am Coll Nutr. 2004 Oct;23(5):529S-533S. [PMID: 15466958]
- Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment. Med Hypotheses. 2006;67(2):362-70. [PMID: 16542786]
Additional references available upon request
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