Vitamin D deficiency is a current epidemic in our society today, affecting 90% of the world`s population. According to Vitamin D expert Michael Holick, `We estimate that vitamin D deficiency is the most common medical condition in the world." It is clear that most people are not getting enough healthy sun exposure.

As a clinician, I see very serious health problems associated with long-term vitamin D3 deficiencies. Vitamin D3 deficiency will impact the development and stability of the immune system, the nervous system, and the endocrine system. 

 Why Is Vitamin D important?

Vitamin D is a fat-soluble vitamin. It’s essential for many areas of your health, including immune health, bone health, muscle health, brain function, and mental health. 

Vitamin D more resembles a hormone than a vitamin by function. Hormones are chemical messengers that interact with cell receptors to produce specific biological responses. Calcitriol, the active form of Vitamin D, is arguably the most powerful hormone in the body. It has the ability to activate over 1,000 genes, which is roughly 5-10% of the human genome.

Vitamin D3 is also shown to boost glutathione production in the neuronal cells and protect them from damage inflicted by oxidative stress. Vitamin D also helps to modulate the immune system to reduce inflammation throughout the body.

What Are Optimal Vitamin D Levels?

Vitamin D3 levels are most often understated. In the medical world, levels below 32 ng/ml are considered sufficient. 

However, much research has shown this level is only sufficient to prevent the development of rickets but not sufficient enough for optimal function (5). 

Functional medicine doctors use the following ranges for optimal vitamin D3 levels. 

Why Is Vitamin K2 Critically Important?

Vitamin K1 is necessary for blood coagulation and is produced by green leafy vegetables. This form of vitamin K helps assist in the formation of anticoagulant factors, protein C & S.

Vitamin K2 is necessary to convert a critical bone-building protein called osteocalcin. Osteocalcin is a necessary protein that helps maintain calcium homeostasis in bone tissue. 

Inadequate K2 inhibits osteocalcin production and reduces calcium flow into bone tissue. This leads to reduced bone mass and a weakened bone matrix.

Vitamin K2 is found in fermented grass-fed dairy, fermented soy (natto), and some fermented veggies. 

Additionally, if one has leaky gut syndrome or a bad microbial balance in their gut (dysbiosis), they will be unable to synthesize enough vitamin K2. 

Most people are not getting adequate vitamin K2 levels due to a diet deficient in fermented foods and the above-mentioned digestive challenges. 

***Vitamin K2 works in synergy with vitamin D and magnesium to help improve calcium metabolism, immune, muscle, and mitochondrial function.  

What is the importance of Magnesium?

Magnesium is an essential cofactor for vitamin D synthesis, and activated vitamin D, in turn, can increase intestinal absorption of magnesium and, therefore, can form a feed-forward loop to maintain its homeostasis.  

Studies have suggested that magnesium could determine the number of vitamin D receptors; therefore, a deficiency in magnesium levels results in a reduced number of available vitamin D receptors in the target cells.

Additionally, magnesium also plays an important role in the conversion of the inactive form of vitamin D in the liver to 25-OH D3 and then into the active 1,25 calcitriol in the kidneys.  

A magnesium deficiency would lead to poor uptake and conversion of D3 and symptoms associated with vitamin D3 deficiency.

What Is The Synergy Between Vitamin D3, Vitamin K2, And Magnesium?

Too much vitamin D3 without the right amount of vitamin K2 and magnesium has been shown to be hazardous. 

Vitamin D3 increases the demand for K2 and magnesium, as well as the potential to benefit through the bone-building proteins osteocalcin and Matrix GLA protein (MGP). 

These proteins activate calcium channels to pull calcium into the bone and out of soft tissue structures. Be sure to consume vitamins D3, K2, and magnesium together for optimal bone and cardiovascular health.

What Is Unique About Our D3/K2 Power?

We formulated D3/K2 Power to contain the optimal ratio of vitamin D3, vitamin K2, and magnesium for optimal cellular function and calcium metabolism.

This formula is the ONLY formula we are aware of that contains this ideal ratio of 5,000 IU of D3, 150 mcg MK-7 form of vitamin K2, and 120 mg of magnesium citrate in a highly absorbable form for optimal delivery of these key nutrients.

What Is The Recommended Dosage? 

Normal Dosage:  1 capsule daily with food (earlier in the day)

Advanced Dosage:  2 capsules daily with food (earlier in the day) for 30–90 days or as recommended by your health care practitioner.

When introducing a new supplement, we recommend taking the lowest dose for 2-3 days. As tolerated, increase the dose until you have reached the recommended normal or advanced guidelines. Reduce to a tolerable dosage if adverse effects occur. 

“MK-7 supplements containing more than 50 mcg/d may interfere with oral anticoagulant treatment (blood thinners), whereas doses of at least 50 mcg are not likely to affect the INR value in a relevant way. (20)”

This supplement does contain 150 mcg of MK-7– so it is not to be used by anyone taking blood thinning treatments.

FAQs

What is the source for Vitamin D3 and Vitamin K2?

Why Choose ImmunoCharge? 

Your immune system is a complex system that protects you from viruses, bacteria, parasites, and other pathogens. It is a complex system that’s essential for your health and survival. 

Optimal immune support is important for your health at all times. As we face more stressful experiences, it is even more important to strengthen our bodies with good immune support nutrients. 

Your body was created to overcome the challenges of the environment.  However, you must be an active participant and work to make your body stronger and more resilient to stress.  Our 10:1 ImmunoCharge formula is designed to help you do that!

What Are The Key Ingredients?

Quercetin:

Quercetin is a plant flavanol from the flavonoid group of polyphenols that adds color to plants and is mostly found in the skin and leaves of various plants.  Some of the best food sources include elderberries, red onions, cranberries, capers, kale, blueberries, and apples.

Quercetin helps to improve the functional properties of immune cells while downregulating the production of inflammatory cytokines and histamines that overstimulate the body’s inflammatory response (1, 2).

Quercetin also works as a zinc ionophore and helps facilitate the movement of zinc into the cell and increase intracellular zinc levels.  This process helps reduce viral replication and improves the inflammatory process (3, 4).  

Zinc:  

Zinc is critical for balancing the immune system and keeping the Th-1 and Th-2 systems in check.  Zinc potentiates the action of the human cytokine interferon alpha, a protein that inhibits viral replication.  This reduces immunological stress and improves the immune coordination (5, 6).

Zinc is also a very specific component of specific enzymes in the body, including superoxide dismutase enzymes (SODs).  SOD is a powerful intracellular antioxidant that protects cellular genomics and prevents viral infection and toxic debris accumulation within the cellular matrix.

Zinc helps improve the body's natural immunological response while keeping inflammatory activity from spiraling out of control (7).  

Vitamin D:  

Vitamin D plays an important role in both innate and adaptive immune responses. The active form of Vitamin D plays a key role in maintaining immune homeostasis (8, 9).  

D3 is an immunomodulator targeting various immune cells, including monocytes, macrophages, and dendritic cells, as well as T-lymphocytes and B-lymphocytes. Numerous large epidemiological studies and meta-analyses have linked inadequate vitamin D levels to a higher susceptibility to immune-mediated disorders, including chronic infections and autoimmune diseases (10, 11)  

N-Acetyl Cysteine:

N-Acetyl Cysteine (NAC) is a source of the essential amino acid L-cysteine, a precursor to the super antioxidant glutathione. Together, NAC and glutathione support the body’s antioxidant and detoxification activity. Glutathione is our most important antioxidant and is often deficient as we age or when we are exposed to a variety of toxins and infections.

NAC also helps to break down excess mucus and acts as a protective shield during cold and flu season (12, 13, 14).  NAC offers the following health benefits:

Vitamin C:

Vitamin C is an essential antioxidant that supports both the innate and adaptive immune response, with decades of research supporting its therapeutic properties.  White blood cells are under enormous oxidative stress when they attack pathogens.  To handle this oxidative stress, they need 50 times more vitamin C inside the cell than in the blood plasma.  

Vitamin C acts to protect the endothelial lining of the blood vessels, lungs, and other important tissues from pathogens and increased oxidative stress.  It also helps to tame down inflammatory cytokines and improve immune coordination (15, 16).

Vitamin C plays a critical role in the anti-viral response by activating the anti-viral interferon – α/β.  It also plays a role in decreasing the pro-inflammatory TNF-alpha and NF-Kb pathways that are associated with a higher rate of inflammatory activity in the body (17).  Vitamin C offers the following health benefits:

 
Selenium:

Selenium (Se) is an essential trace mineral that, through its incorporation into selenoproteins, plays a pivotal role in maintaining optimal health. Insufficient intake of Se enhances predisposition to diseases associated with oxidative stress to cells and tissues, while supplementation above the recommended levels has been shown to confer health benefits such as enhanced immune competence and resistance to viral infections, and in animal models and human studies (18).

Selenium status is known to influence the functioning of all components of the immune system and its ability to respond to infections and cancers; Se is found in significant amounts in immune tissues such as the spleen, lymph nodes, and liver.  

A selenium deficiency leads to reduced function of all immune cells and higher rates of viral infection and inflammation.  Adequate levels of Se are important for initiating immunity, but they are also involved in regulating excessive immune responses and chronic inflammation (19).  Selenium offers the following health benefits:

 

Resveratrol:

Resveratrol is the most well-known polyphenolic stilbenoid, present in grapes, blueberries, mulberries, rhubarb, and several other plants. 

Resveratrol regulates immunity by interfering with immune cell regulation, proinflammatory cytokines’ synthesis, and gene expression.  The effects of this biologically active compound on the immune system are associated with widespread health benefits.

Resveratrol has been shown to improve the immune response to various environmental challenges by regulating the renin-angiotensin system (RAS) and the expression of angiotensin-converting enzyme 2 (ACE2) and downregulating pro-inflammatory cytokine release.  It was also reported to promote SIRT1 and p53 signaling pathways and increase cytotoxic T lymphocytes (CTLs) and natural killer (NK) immune cells.

Magnesium:  

Magnesium is one of the most abundant minerals in the human body and is used in over 300 different physiological processes. Unfortunately, magnesium is also one of the most pervasive deficiencies in our society today. 

Magnesium and vitamin A are critical for the activation of vitamin D, and many people will supplement with vitamin D but not get the desired benefit due to deficiencies in magnesium and vitamin A.

A magnesium deficiency is associated with higher levels of inflammation, susceptibility to infection, trouble sleeping, muscle cramping, pain, and poor healing processes (22).  Magnesium offers the following health benefits

 

Vitamin A:  

Vitamin A is an essential micronutrient for immunity, cellular differentiation, growth, reproduction, maintenance of epithelial surfaces, and vision.  Vitamin A plays a critical role in the proper development of the mucosal membranes and the growth and activation of T and B-cells (23).

The epithelium lines all outer surfaces and most inner surfaces of organisms, and it functions as the “front line” of defense against pathogen invasion.  Vitamin A is critical for the development and protection of these surfaces and the production of the mucosal membranes that house the antigen's non-specific immune defense.

Vitamin A also plays a critical role in the activation of vitamin D within the cell, so it can carry out its desired effect.  A vitamin A deficiency leads to higher viral and bacterial infection rates and higher morbidity and mortality associated with infectious diseases (24).  

 

Vitamin K2:  

Vitamin K is a fat-soluble nutrient that plays a critical role in blood clotting and calcium metabolism.  It is found in 2 major forms

Vitamin K1 (phylloquinone) is found in leafy green vegetables

Vitamin K2 (menaquinone) is found in dairy, egg yolk, fermented foods, and animal products.

Although these metabolites are both labeled in the vitamin K category, they have different functions.  Vitamin K1 is critical for blood clotting, while vitamin K2 works as a vacuum, getting calcium out of the bloodstream and into the bones. This helps improve arterial health, blood flow, and oxygenation into deep tissues of the body (25).

Vitamin K2 also plays an important role in immune health and synergizes with vitamin D to optimize cardiovascular, dental, and bone health. Insufficient levels of vitamin K2 are thought to increase the risk of cardiovascular calcifications and bone loss (26).  

Vitamin K2 has also been shown to be an immunomodulator, which helps improve the inflammatory response, which may also be a contributing factor in improving cardiovascular and bone health (27, 28).  Vitamin K2 offers the following health benefits

 

What Is ImmunoCharge?

ImmunoCharge is specifically designed to provide you with optimal dosages of these key immune-modulating nutrients and compounds.  The synergy of these key nutrients and compounds strengthens immune function and improves the process of inflammation.

Each ImmunoCharge capsule contains the same amount of powerful immune-modulating compounds.  These include quercetin, resveratrol, vitamin D, vitamin A, selenium, zinc, vitamin C, N-Acetyl Cysteine, vitamin K2, and magnesium.  

These ingredients support the body's natural immune mechanism to help maintain good health.  Rather than taking multiple different supplements to get these key nutrients, you can get the clinical dosages within 2 capsules daily of ImmunoCharge. 

What Is The Recommended Dosage?

Normal Dosage:  Take 1 capsule, 2 times daily with meals for optimal absorption, or as directed by your healthcare practitioner.

Advanced Dosage:  Take 2 capsules, 2 times daily with meals for optimal absorption, or as directed by your healthcare practitioner.

This supplement can be used short term or on a continual basis for added antioxidant and overall health support.

When introducing a new supplement, we recommend taking the lowest dose for 2-3 days. As tolerated, increase the dose until you have reached the recommended normal or advanced guidelines. Reduce to a tolerable dosage if adverse effects occur. 

Consult your healthcare practitioner before use.  Individuals taking medication should discuss potential interactions with their healthcare practitioner.  Do not use if the tamper seal is damaged.

 

Why Choose Zinc Defense?

Stop letting seasonal bugs dictate your life. Your immune system is your primary shield against invisible threats, yet standard vitamins often fall short. 

Introducing Zinc Defense, the ultimate all-in-one cellular fortress designed to keep you performing at your peak year-round. 

Most people take zinc when they feel a scratchy throat, but standard zinc supplements struggle to actually enter your cells where they are needed most. 

Zinc Defense solves this biological bottleneck. By combining premium zinc with a synergistic matrix of copper, quercetin, and N-Acetyl Cysteine (NAC), this formula unlocks maximum bioavailability and comprehensive defense.

Why Is Zinc Defense Different?

Zinc is powerful, but it cannot fight alone. To cross the cellular membrane effectively, zinc requires a transporter.

That is where quercetin comes in. As a natural plant flavonoid,  quercetin acts as an "ionophore"—a key that unlocks your cells to let zinc flood inside. Once inside, zinc can actively disrupt viral replication and protect your health.

Furthermore, high doses of zinc can deplete your body's essential copper  levels over time. Zinc Defense includes a perfectly balanced dose of copper to prevent this deficiency,  keeping your nervous system and cardiovascular health fully supported.

Finally, we supercharged this formula with NAC. As a precursor to glutathione—the body's master antioxidant—NAC thins stubborn mucus, clears bronchial pathways, and neutralizes free radicals caused by environmental stress.

The Power of Four: Inside the Zinc Defense Matrix

Zinc Defense combines four premium, bioavailable ingredients into a single, high-potency daily serving. Every ingredient is precisely dosed to maximize performance and eliminate side effects.

1. High-Potency Bioavailable Zinc: We use the most absorbable forms of zinc to ensure maximum systemic uptake. This vital mineral immediately goes to work supporting white blood cell production, maintaining structural skin barriers, and reinforcing your primary immune pathways.
2. Quercetin (The Cellular Key): Quercetin is a potent, plant-based antioxidant that acts as a natural zinc ionophore. Think of quercetin as a VIP security escort. It binds to the zinc molecules and directly forces them through the cellular membrane, straight into the center of the cell where you need it most. With quercetin, your zinc absorption multiplies exponentially. Quercetin is also a potent antioxidant that has anti-histamine and anti-inflammatory properties.
3. N-Acetyl Cysteine / NAC (The Detox Pioneer)
   NAC is the ultimate precursor to glutathione—your body’s master antioxidant.
   While zinc and quercetin protect the cell exterior and interior, NAC works from within to mop up free radicals, support optimal respiratory and lung function, and deeply detoxify your liver.
4. Balanced Copper Chelate (The Biological Counterweight):
   To eliminate the copper depletion trap completely, we included a perfectly balanced dose of premium copper chelate. This ensures your zinc-to-copper ratio remains in the golden biological zone, protecting your neurological health, energy production, and collagen synthesis.

What Is The Recommended Dosage?

Normal Dosage: Take 1 capsule, 1 time daily with meals

Advanced Dosage: Take 1 capsule, 2 times daily with meals or as directed by your healthcare provider.

When introducing a new supplement, we recommend taking the lowest dose for 2-3 days. As tolerated, increase the dose until you have reached the recommended normal or advanced guidelines. Reduce to a tolerable dosage if adverse effects occur.

Why Choose CortiClear Focus PS?

CortiClear Focus PS features 150 mg of non-soy, sunflower-sourced phosphatidylserine (PS) per capsule. Phosphatidylserine is a nutrient that is essential for supporting optimal brain function. There are no foods rich in phosphatidylserine; therefore, supplementation is the only way to support healthy levels of this valuable brain nutrient. The body can make phosphatidylserine, but in far from ideal quantities, and natural production of PS decreases as we age.

Brain function is at its peak in the 20s and then naturally declines throughout the rest of life. In the 40s, many people begin to notice subtle changes in cognition and memory. This decline may be caused by the depletion of nutrients that help maintain the integrity of the membrane of brain cells, the cell's protective outer layer. Phosphatidylserine works by rejuvenating and strengthening this membrane, which helps support brain function and may help with absent-mindedness that can result from the normal aging process.

What Is The Recommended Dosage?

Take 1 capsule per day, or as directed by your health-care practitioner. As with any brain-energizing nutrient, phosphatidylserine is best avoided near bedtime as it may interfere with falling asleep.

When introducing a new supplement, we recommend taking the lowest dose for 2-3 days. As tolerated, increase the dose until you have reached the recommended normal or advanced guidelines. Reduce to a tolerable dosage if adverse effects occur.

FAQ's:

Why is supplementation important for phosphatidylserine?

There are no foods rich in phosphatidylserine, making supplementation the only way to support healthy levels. While the body can produce PS, it does so in far from ideal quantities, and natural production decreases with age. This makes supplementation particularly important for supporting brain function and memory as we age.

How does CortiClear Focus PS differ from Phosphatidylcholine?

CortiClear Focus PS provides phosphatidylserine, which is specifically targeted for brain function, memory, neuron communication, and cortisol normalization. Phosphatidylcholine is primarily targeted for liver health, cell membrane integrity throughout the body, acetylcholine production, and fat metabolism. Both are phospholipids essential for cell membrane health, but they serve different primary functions. PS 150 is ideal for brain and cognitive support, while Phosphatidylcholine is ideal for liver and whole-body cell membrane support.

Who may benefit most from CortiClear Focus PS?

Individuals noticing age-related changes in memory or cognitive function, those under chronic stress who may benefit from cortisol normalization, athletes engaging in intense exercise who want to support healthy testosterone-to-cortisol ratios, and anyone seeking a non-soy, sunflower-sourced brain-support nutrient.