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ImmunoCharge ImmunoCharge ImmunoCharge ImmunoCharge

ImmunoCharge

Dr. Jockers

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ImmunoCharge

Your immune system is a complex system that protects you from viruses, bacteria, parasites, and other pathogens. It is a complex system that’s essential for your health and survival. 

Optimal immune support is important for your health at all times. As we face more stressful experiences it is even more important to strengthen your body with good immune support nutrients. 

Your body was created to overcome the challenges from the environment.  However, you must be an active participant and work to make your body stronger and more resilient to stress.  Our 10:1 ImmunoCharge formula is designed to help you do that!

 

Quercetin:

Quercetin is a plant flavanol from the flavonoid group of polyphenols that adds color to plants and is mostly found in the skin and leaves of various plants.  Some of the best food sources include elderberry, red onions, cranberries, capers, kale, blueberries and apples.

Quercetin helps to improve the functional properties of immune cells while downregulating the production of inflammatory cytokines and histamines that over stimulate the body’s inflammatory response (1, 2).

Quercetin also works as a zinc ionophore and helps facilitate the movement of zinc into the cell and increase intracellular zinc levels.  This process helps reduce viral replication and improves the inflammatory process (3, 4).  


 

Zinc:  

Zinc is critical for balancing the immune system and keeping the Th-1 and Th-2 systems in check.  Zinc potentiates the action of the human cytokine interferon alpha, a protein that inhibits viral replication.  This reduces immunological stress and improves the immune coordination (5, 6).

Zinc is also a very specific component of specific enzymes in the body including superoxide dismutatse enzymes (SODs).  SOD is a powerful intracellular antioxidant that protects the cellular genomics and prevents against viral infection and toxic debris accumulation within the cellular matrix.

Zinc helps improve the bodies natural immunological response while keeping inflammatory activity from spiraling out of control (7).  


 

Vitamin D:  

Vitamin D plays an important role in both innate and adaptive immune responses. The active form of Vitamin D plays a key role in maintaining immune homeostasis (8, 9).  

D3 is an immunomodulator targeting various immune cells, including monocytes, macrophages, dendritic cells, as well as T-lymphocytes and B-lymphocytes. Numerous large epidemiological studies and meta-analysis have linked inadequate vitamin D levels to a higher susceptibility of immune-mediated disorders including chronic infections and autoimmune diseases (10, 11)  


 

N-Acetyl Cysteine:

N-Acetyl Cysteine (NAC) is a source of essential amino acid L-cysteine, a precursor to the super antioxidant glutathione. Together, NAC and glutathione support the body’s antioxidant and detoxification activity. Glutathione is our most important antioxidant and is often deficient as we age or when we are exposed to a variety of toxins and infections.

NAC also helps to break down excess mucus and acts as a protective shield during cold and flu season (12, 13, 14).  NAC offers the following health benefits:


 

Vitamin C:

Vitamin C is an essential antioxidant that supports both the innate and adaptive immune response with decades of research supporting its therapeutic properties.  White blood cells are under enormous oxidative stress when they attack pathogens.  To handle this oxidative stress, they need 50 times more vitamin C inside the cell than in the blood plasma.  

Vitamin C acts to protect the endothelial lining of the blood vessels, lungs and other important tissues from pathogens and increased oxidative stress.  It also helps to tamper down inflammatory cytokines and improves immune coordination (15, 16).

Vitamin C plays a critical role in the anti-viral response by activating the anti-viral interferon – α/β.  It also plays a role in decreasing the pro-inflammatory TNF-alpha and NF-Kb pathways that are associated with a higher rate of inflammatory activity in the body (17).  Vitamin C offers the following health benefits:

 

Selenium:

Selenium (Se) is an essential trace mineral that, through its incorporation into selenoproteins, plays a pivotal role in maintaining optimal health. Insufficient intake of Se enhances predisposition to diseases associated with oxidative stress to cells and tissues while supplementation above the recommended levels has been shown to confer health benefits such as enhanced immune competence and resistance to viral infections and in animal models and human studies (18).

Selenium status is known to influence the functioning of all components of the immune system and its ability to respond to infections and cancers; Se is found in significant amounts in immune tissues such as spleen, lymph nodes and liver.  

A selenium deficiency leads to reduced function of all immune cells and higher rates of viral infection and inflammation.  Adequate levels of Se are important for initiating immunity, but they are also involved in regulating excessive immune responses and chronic inflammation (19).  Selenium offers the following health benefits:

 

 

Resveratrol:

Resveratrol is the most well-known polyphenolic stilbenoid, present in grapes, blueberries, mulberries, rhubarb, and in several other plants. Resveratrol can play a beneficial role in the prevention and in the progression of chronic diseases related to inflammation such as diabetes, obesity, cardiovascular diseases, neurodegeneration, and cancers among other conditions. 

Moreover, resveratrol regulates immunity by interfering with immune cell regulation, proinflammatory cytokines’ synthesis, and gene expression.  The effects of this biologically active compound on the immune system are associated with widespread health benefits for different autoimmune and chronic inflammatory diseases (20).

The antiviral efficacy of Resveratrol has been demonstrated for several important viruses, including coronavirus. Resveratrol was shown to mitigate the major pathways involved in the pathogenesis of SARS-CoV-2, including regulation of the renin-angiotensin system (RAS) and expression of angiotensin-converting enzyme 2 (ACE2), stimulation of immune system and downregulation of pro-inflammatory cytokines release. It was also reported to promote SIRT1 and p53 signaling pathways and increase cytotoxic T lymphocytes (CTLs) and natural killer (NK) immune cells. (21)

 

Magnesium:  

Magnesium is one of the most abundant minerals in the human body and is used in over 300 different physiological processes. Unfortunately, magnesium is also one of the most pervasive deficiencies in our society today. 

Magnesium and vitamin A are critical for the activation of vitamin D and many people will supplement with vitamin D but not get the desired benefit due to deficiencies in magnesium and vitamin A.

A magnesium deficiency is associated with higher levels of inflammation, susceptibility to infection, trouble sleeping, muscle cramping, pain and poor healing processes (22).  Magnesium offers the following health benefits

     


    Vitamin A:  

    Vitamin A is an essential micronutrient for immunity, cellular differentiation, growth, reproduction, maintenance of epithelial surfaces and vision.  Vitamin A plays a critical role in the proper development of the mucosal membranes and in the growth and activation of T and B-cells (23).

    The epithelium lines all outer surface and most inner surfaces of organisms, and it functions as the “front line” of defense against pathogen invasion.  Vitamin A is critical for the development and protection of these surfaces and the production of the mucosal membranes which house the antigen non-specific immune defense.

    Vitamin A also plays a critical role in the activation of vitamin D within the cell so it can carry out its desired effect.  A vitamin A deficiency leads to higher viral and bacterial infection rates and higher morbidity and mortality associated with infectious diseases (24).  

     


    Vitamin K2:  

    Vitamin K is a fat-soluble nutrient that plays a critical role in blood clotting and calcium metabolism.  It is found in 2 major forms

    Vitamin K1 (phylloquinone) found in leafy green vegetables

    Vitamin K2 (menaquinone) found in dairy, egg yolk, fermented foods and animal products.

    Although these metabolites are both labeled in the vitamin K category, they have different functions.  Vitamin K1 is critical for blood clotting while vitamin K2 works as a vacuum getting calcium out of the blood stream and into the bones. This helps improve arterial health, blood flow and oxygenation into deep tissues of the body (25).

    Vitamin K2 also plays an important role in immune health and synergizes with vitamin D to optimize cardiovascular, dental and bone health. Insufficient levels of vitamin K2 are thought to increase the risk of cardiovascular calcifications and bone loss (26).  

    Vitamin K2 has also been shown to be an immunomodulator which helps improve the inflammatory response which may also be a contributing factor in improving cardiovascular and bone health (27, 28).  Vitamin K2 offers the following health benefits

     


    Introducing ImmunoCharge:

    ImmunoCharge is specifically designed to provide you with optimal dosages of these key immune modulating nutrients and compounds.  The synergy of these key nutrients and compounds strengthens immune function and improves the process of inflammation.

    Each ImmunoCharge capsule contains the same amount of powerful immune modulating compounds.  These include quercetin, resveratrol, vitamin D, vitamin A, selenium, zinc, vitamin C, N-Acetyl Cysteine, vitamin K2 and magnesium.  

    These ingredients support the body's natural immune mechanism to help maintain good health.  Rather than taking multiple different supplements to get these key nutrients, you can get the clinical dosages within 4 capsules daily of ImmunoCharge. 

    Directions:  

    Normal Dosage:  Take 2 capsules, 2 times daily with meals for optimal absorption, or as directed by your healthcare practitioner.

     

    Advanced Dosage:  Take 3-4 capsules, 2 times daily with meals for optimal absorption, or as directed by your healthcare practitioner.

     

    Consult your healthcare practitioner prior to use.  Individuals taking medication should discuss potential interactions with their healthcare practitioner.  Do not use if tamper seal is damaged.



    Sources for This Include:

    1. https://pubmed.ncbi.nlm.nih.gov/27187333/
    2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227109/ 
    3. https://pubmed.ncbi.nlm.nih.gov/25050823/
    4. https://journals.sagepub.com/doi/full/10.1177/1934578X20976293 
    5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628855/
    6. https://pubmed.ncbi.nlm.nih.gov/34514483/
    7. https://pubmed.ncbi.nlm.nih.gov/25462582/
    8. https://pubmed.ncbi.nlm.nih.gov/30400332/
    9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281985/
    10. https://pubmed.ncbi.nlm.nih.gov/21242105/ 
    11. https://pubmed.ncbi.nlm.nih.gov/31323357/ 
    1. https://pubmed.ncbi.nlm.nih.gov/30701862/
    2. https://pubmed.ncbi.nlm.nih.gov/29742938/
    3. https://pubmed.ncbi.nlm.nih.gov/33177829/
    4. https://pubmed.ncbi.nlm.nih.gov/24792921/
    5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707683/
    6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659258/
    7. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1747-0080.2008.00260.x
    8. https://pubmed.ncbi.nlm.nih.gov/21955027/
    9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566902/
    10. https://pubmed.ncbi.nlm.nih.gov/32985211/
    11. https://www.nature.com/articles/1601689
    12. https://pubmed.ncbi.nlm.nih.gov/30200565/
    13. https://academic.oup.com/jid/article-abstract/223/10/1806/5909831?redirectedFrom=fulltext
    14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413124/
    15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566462/
    16. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831512/
    17. https://pubmed.ncbi.nlm.nih.gov/33390552/
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