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According to the American Diabetes Association 29.1 million Americans (9.3% of the population) have diabetes and another 86 million people (18.8%) have insulin-resistant pre-diabetes (1). The vast majority of diabetes is the type II variety known as degenerative diabetes. Research has shown that degenerative diabetes is an inflammatory disorder and is completely preventable & reversible through an anti-inflammatory lifestyle.
When we eat sugar or carbohydrates our digestive system converts these larger molecules into glucose which is then absorbed into the bloodstream and taken to every cell of the body. Blood sugar fuels the cells keeping them healthy. For healthy function it is critical to maintain stable blood sugar levels.
The Dangers of Elevated Blood Sugar:
When blood sugar is elevated the sugar molecules connect to protein enzymes in the body producing sticky enzymes in a process called glycation. These glycation products are named advanced glycolytic enzymes (AGE’s) and they produce rampant amounts of oxidative stress, inflammation and tissue damage.
The body naturally produces the hormone insulin in order to shunt the sugar out of the bloodstream and into the cells where it can be used for energy. Under circumstances of chronic sugar and carbohydrate consumption and/or chronic inflammation the insulin receptors become unable to effectively do their job. This is called insulin resistance, a condition that increases the level of glycation and resulting tissue damage in the body (1).
Glycation is the process that leads to atrocious conditions such as diabetic neuropathy, optic nerve destruction and resulting diabetic blindness and diabetic induced kidney failure (2,3). Controlling glycation and the destructive effects of glycation is critical. Certain anti-oxidant and trace mineral compounds have been found to be highly effective at combatting the damaging effects of glycation and improving blood sugar signaling patterns.
Introducing Insulin Manager:
Insulin Manager™ is an extraordinary combination of herbal and nutrient support for healthy glucose metabolism. It features concentrates of fenugreek, gymnema and bitter gourd, the addition of high levels of vanadium along with select B vitamins and the mineral, chromium. This formula provides nutritional support for glucose and insulin metabolism and supports healthy blood lipid levels already within the normal range*
Nearly 50% of the US population is deficient in chromium which is greater than any other developed nation. This is due to over cropping that has stripped the land of chromium and processed food consumption. Chromium deficiencies lead to diabetes and heart disease.
Chromium helps to activate the glucose transporter molecule within the cell called GLUT4. The GLUT4 receptor is found most abundantly in skeletal muscle and fat tissue where most glucose metabolism takes place (4, 5).
Chromium activates GLUT4 and it positions itself right on the surface of the cell membrane where it is easily able to interact with insulin and glucose (6). This allows glucose to pass from high concentrations in the blood to low concentrations in the cell through the GLUT4 bridge.
Chromium based studies have repeatedly demonstrated improvement in blood sugar levels, insulin sensitivity and lipid profiles. Chromium modulates the cells intracellular signaling systems to effectively lower blood glucose (7, 8, 9, 10).
One of the most effective natural treatments for diabetes is vanadium. This unique trace mineral works to lower blood sugar by mimicking insulin and improving the cells’ sensitivity to insulin (11, 12, 13).
Thiamin activates glyceraldehyde phosphate dehydrogenase (GAPDH). Decreased availability of this enzyme has been implicated in diabetes complications such as blindness, nerve damage, kidney failure, stroke and cardiovascular disease (14)
Thiamin repletion in the case of a six year-old girl with diabetes caused by a genetic mutation effecting thiamine transport demonstrated its benefits (15). Thiamin deficiency may cause diabetic neuropathy by decreasing transketolase, needed for normal myelinization and thiamine monophasphatase, needed for primary sensory neuron function (16)
Niacin is required for lipid metabolism, tissue respiration and glycogenolysis. It may preserve and protect Beta cells (17) Niacinamide improved insulin secretion in lean diabetics who had failed drug treatment (18).
Biotin helps support adrenal function, help calm and maintain a healthy nervous system, and are necessary for key metabolic processes. Biotin is nicknamed “the beauty vitamin,” because of its association with healthy hair, skin and nails.
Biotin, in very large doses (5-15 mgs) enhances the effects of enzymes involved in glucose metabolism. One small study even demonstrated the reversal of diabetic neuropathy (19).
Chromium and Biotin synergistically improve glucose tolerance (20)
Fenugreek Seed and its constituent, 4-isoleucine appear to directly stimulate insulin (21). The combination of fenugreek with vanadium appeared to normalize altered membrane linked functions and GLUT4 distribution (22). Fenugreek also lowered high serum cholesterol and triglycerides.
Bitter Gourd (aka. bitter melon) contains an insulin-like polypeptide shown to exhibit hypoglycemic effects (23) with an onset of action between 30-60 minutes and a peak effect at about 4 hours (24). It is approved as an antidiabetic drug in China (25).
Gymnema sylvestre reduced fasting blood sugars, glycosylated hemoglobin (HbA1c) and glycosylated plasma protein levels and thus insulin requirements in Type 1 diabetics by reducing glucose absorption in the intestine, stimulating pancreatic beta cell growth and possibly increasing endogenous insulin secretion as suggested by an increase in C-peptide levels. Gymnema was shown to also reduce serum triglycerides, total cholesterol, VLDL and LDL (26).
Why I Love This Supplement:
Unstable blood sugar is one of the first areas I focus on in order to help my clients improve their health and especially when we are trying to reverse chronic disease processes. This supplement has an incredible blend of clinically researched nutrients that support healthy blood sugar. From my clinical experience, Insulin Manager works quickly and powerfully to stabilize blood sugar and reduce inflammation.
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