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Aging and high levels of physical, chemical and emotional stress are associated with the loss of progesterone in women and testosterone in men. When these key hormones are depleted it causes a state of estrogen dominance. This state of estrogen dominance is one of the major factors associated with degenerative disease processes.
“As a species, we`re on a fast track to extinction,” says Ori Hofmekler, author of The Anti-Estrogenic Diet. “In the past few decades, men have lost 50% of their sperm count and within only one generation, the average man’s sperm count and testosterone have dropped by 20%. Women are no better. Staggering figures show that most women today are suffering from female disorders and three out of ten women between the ages of 35 to 60 will develop breast cancer.”
Symptoms of Estrogen Dominance:
Estrogen hormones are metabolized by the liver through a hydroxylation process in phase I liver detoxification. The hydroxylation process takes place on 3 major estrogen molecules. These include 2-hydroxyestrone (2-OH), 4-hydroxyestrone (4-OH) and 16-alpha-hydroxyestrone (16-alpha-OH).
The 2-OH metabolite has a very mild estrogenic response and is the preferential estrogen metabolite. The 4-OH and 16-alpha OH are much more powerful and create a persistent estrogenic response. Compounds that help reduce the 4-OH and 16-alpha OH subtypes and increase 2-OH are desired for good estrogen metabolism.
Estro-Protect Balances Estrogen Metabolites:
Estro-Protect uses a dual-action approach to supporting healthy estrogen-sensitive tissues. First, it provides diindolylmethane (DIM) to promote healthy estrogen metabolism and create a better balance of estrogen metabolites (2-OH, 4-OH, 16alpha-OH) through phase I cytochrome P450 enzyme induction and promotion of 2-hydroxylation.
Second, the action of DIM is complemented by providing sulforaphane glucosinolate (SGS), which protects tissues from unrestrained oxidative stress and uniquely supports phase II detoxification of harmful estrogen metabolites (e.g., estrogen quinones) and xenoestrogens.
DIM and Your Estrogen Ratio:
These actions may be important for the health of estrogen-sensitive tissues, such as those of the breast, uterus, cervix, and prostate. DIM (diindolylmethane) DIM is an advanced metabolite of indole-3-carbinol (I3C), the indole found in cruciferous vegetables. Supplementation with DIM is preferred over I3C due to I3C’s undesirable breakdown products, including the dioxin-like molecule indolo[3,2-b] carbazole (ICZ) (1).
It has been established that DIM supplementation increases 2-hydroxylation of estrogen. This science has been validated in animal and human studies wherein supplementation with DIM was shown to increase the ratio of the protective, “good” 2-hydroxyestrone (2-OH) to 16alpha hydroxyestrone (16alpha-OH) (2, 3).
In a study of postmenopausal women, DIM-treated subjects, relative to placebo, showed an increase of 47% in 2-OH/16alpha-OH (4). Studies further reveal that DIM may play a critical role in supporting normal cellular proliferation in estrogen-sensitive tissues (3,5,6).
Broccoli Seed ExtractSulforaphane Glucosinolate (SGS)
Broccoli seed extract is renowned for being such a powerful estrogen detoxifier and anti-oxidant amplifier. Sulfuraphane Glucosinolate (SGS) is the major component that gives it this extraordinary ability. The SGS broccoli seed extract used in Estro-Protect is a super vegetable that delivers extended antioxidant support and boasts a very high level of glucoraphanin (13%).
Research suggests that when SGS is broken down to sulforaphane (its active form), it safely and effectively upregulates the Nrf2 system, activates the antioxidant response element (ARE), enhances the production of important antioxidants, and activates vital phase II detoxification enzymes (7).
These mechanisms provide protection from toxins, xenobiotics (e.g., xenoestrogens), and reactive intermediates formed after phase I detoxification.*
Neutralizing Bad Estrogen Metabolites
Neutralizing reactive estrogen metabolites with SGS According to Bolton et al, the oxidation of catechol estrogens (2-OH and 4-OH) via cytochrome P450 enzymes generates reactive electrophilic estrogen quinones and reactive oxygen species (ROS) through redox cycling (8).
Formation of quinones is largely minimized via phase II methylation, which produces methoxyestrogens. However, if methylation is suboptimal, estrogen quinones, which can cause DNA damage in estrogen-sensitive tissues, must be neutralized via other phase II enzymes such as quinone reductase. According to researchers, estrogen quinones are now recognized as a significant mechanism of estrogen-mediated cell damage (8,9)
A promising strategy to address their deleterious effects involves the use of agents to favorably shift the balance between phase I and phase II enzymes (9). In fact, phase II enzymes such as quinone reductase, heme oxygenase-1 (HO-1), and glutathione S-transferase (GST) have been suggested as targets for reducing these highly reactive estrogen quinones.*
Powerful Liver Detoxification Agents:
Sulforaphane has been identified as an agent that possesses the ability to potently induce phase II detoxification enzymes—including quinone reductase, HO-1, GST, and glutathione reductase—as well as to inhibit phase I enzymes involved in activation (10, 11, 12) In the case of estrogen quinones, quinone reductase protects cells from oxidative damage by two-electron reduction, thus suppressing oxidative cycling and reactive oxygen species generation (10).
Sulforaphane consumption is associated with supporting cell-line health in humans, and animal research shows that sulforaphane metabolites can be found in target tissues, along with significant induction of quinone reductase and HO-1. This research has exciting implications for supporting the health of tissues as it relates to reactive estrogen quinones formed after phase I activation of catechol estrogens (2-OH, 4-OH).*
Benefits of Estro-Protect:
As a clinician, I see so many men and women struggling with estrogen dominance and the related symptoms. This supplement gives me confidence as a practitioner that I can help these individuals get over these issues much quicker than by simply making lifestyle changes.
This supplement is a key for most individuals struggling with menstrual issues, menopausal problems, endometriosis, PCOS, uterine fibroids, estrogen dominant cancers, etc.
Additionally, most men with prostate cancer and/or low testosterone levels respond very well to this supplement.
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