Vitamin B6 - Pyridoxal 5'-Phosphate (P-5-P)
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Vitamin B6 - Pyridoxal 5'-Phosphate (P-5-P) Vitamin B6 - Pyridoxal 5'-Phosphate (P-5-P)

Vitamin B6 - Pyridoxal 5'-Phosphate (P-5-P)

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Vitamin B6

Pyridoxal 5'-Phosphate (P-5-P) 60 Count The Bioactive, Tissue-Ready Form of Vitamin B6*

  • The active form of Vitamin B6 more readily used by the body*
  • Essential cofactor for synthesis of amino acids and numerous neurotransmitters (brain chemicals)*
  • Not derived from yeast

Pyridoxine, also known as vitamin B6, is necessary for the transformation and utilization of amino acids for many functions in the body, including energy production and neurotransmitter synthesis. Vitamin B6 is also involved in the production of hemoglobin, intrinsic factor, and is a vital component in the formation of the myelin sheath that surrounds nerve cells.


Causes of B6 Deficiency:

Vitamin B6 deficiency can be caused by excess consumption of alcohol, sugary foods and processed foods.  Poor gut health, high exposure to environmental toxins and many pharmaceutical drugs will lower levels of B6 1

As we grow during our teenage years we typically need more B6.  Many individuals today struggle with poor digestive health and bacterial dysbiosis.  Gut bacteria play an important role in the production and utilization of B6.  Small intestinal bacterial overgrowth, parasites and candida overgrowth can all hamper B6 production. 


B6 Deficiency a Widespread Problem:

Although not widely recognized, poor vitamin B6 status may be relatively common in individuals eating a Standard American Diet.2  In the United States, a remarkably high number of adults—90% of women and 71% percent of men—consume diets that are deficient in vitamin B6 using the Recommended Dietary Allowance (RDA) as a measure.3 

Furthermore, according to recent national health data, many individuals have inadequate vitamin B6 status despite meeting the RDA of B6 from their diets.But a probable common cause for the poor status of some is a low intake of foods rich in highly bioavailable vitamin B6.


The Problem With Most B6 on the Market

The most common form of vitamin B6 that is sold on the market is in the form of Pyridoxine hydrochloride (PNHCl). When compared with pyridoxal-5-phosphate (P-5-P) supplements, PNHCl requires an additional enzymatic step in the liver to be converted to the form utilizable by the body.5,6 

Many practitioners recommend P-5-P supplements over PNHCl supplements for this reason1 and because there have been more reports of adverse effects with use of high doses of pyridoxine.7

But in order for pyridoxine to be used by the body it must first be converted to pyridoxal 5'-phosphate (P5P), a process that takes place in the liver.

Individuals with compromised liver function have difficulty making this conversion and consequently may be at risk of a vitamin B6 deficiency.

Supplementing with Thorne Research's Pyridoxal 5'-Phosphate ensures you receive the most bioactive form of vitamin B6.

Normal Dosage:    1 cap – 1 time daily (with or without food)

Advanced Dosage:  1 cap – 2-3 times daily (with or without food)

One Capsule Contains:
Vitamin B6 (as Pyridoxal 5'-Phosphate) 33.8 mg.

Other Ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Calcium Laurate, Silicon Dioxide. 



  1. Stargrove MB, Treasure J, McKee DL. Herb, Nutrient, and Drug Interactions: Clinical Implications and Therapeutic Strategies. St. Louis, Mo: Elsevier Mosby; 20082. Azuma J, Kishi T, Williams RH, Folkers K. Apparent deficiency of vitamin B6in typical individuals who commonly serve as normal controls. Res Commun Chem Pathol Pharmacol1976;14:343-366
  2. Kant AK, Block G. Dietary vitamin B6intake and food sources in the US population: NHANES II, 1976-1980. Am J Clin Nutr 1990;52:707-716
  3. Morris MS, Picciano MF, Jacques PF, Selhub J.Plasma pyridoxal 5’-phosphate in the US population: the National Health and Nutrition Examination Survey, 2003-2004. Am J Clin Nutr.2008;87:1446-54
  4. Mackey AD, Davis SR, Gregory JF III. Vitamin B6. In:Shils ME, Shike M, Ross AC, Caballero B, Cousins RJ, eds. Modern Nutrition in Health and Disease.Baltimore Md: Lippincott Williams & Wilkins; 2006:452-461
  5. Kang-Yoon SA, Kirksey A, Giacoia GP, West KD. Vitamin B6adequacy in neonatal nutrition: associations with preterm delivery, type of feeding and vitamin B6supplementation. Am J Clin Nutr. 1995;62:932-942
  6. Clayton PT. B6-responsive disorders: a model of vitamin dependency. J Inherit Metab Dis. 2006;29:317-326


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