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Homocysteine Support Homocysteine Support

Homocysteine Support

Designs for Health

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Homocysteine Support™ contains synergistic nutrients known to facilitate the efficient metabolism of homocysteine. Homocysteine Support™ maintains a healthy homocysteine pathway, allowing for the normal production of its necessary and important end products.

These include the sulfur-containing amino acids taurine and cysteine, and the neurotransmitters norepinephrine and dopamine.*

An optimally functioning homocysteine pathway provides methyl and sulfur groups for biochemical reactions such as detoxification, healthy immune function, ideal joint and cartilage structure, and brain and cardiovascular health.

When Does Dr Jockers Use This?

I use this product when I see elevated homocysteine over 9 umol/L in order to protect our brain and vascular tissue.  My team tests homocysteine on nearly all of our coaching clients and we highly recommend everyone test this biomarker at least one time per year. 

High homocysteine levels over 9 umol/L are associated with an increased risk of neuronal degeneration and cardiovascular events.  Providing the proper methylation support can help to reduce homocysteine into a safe level and improve neuronal and cardiovascular health. 

Normal Dosage:  Take 1 cap – 2x daily with or without food

Advanced Dosage:  Take 2 caps – 2x daily with or without food

***Warning:  Please consult your healthcare professional before using if you are pregnant, breastfeeding or considering use for a child.

 

What are Your Homocysteine Levels?

Homocysteine is an inflammatory amino acid that is produced as a byproduct of protein metabolism. Homocysteine-induced injury to the arterial wall is one of the factors that can initiate the process of atherosclerosis, leading to endothelial dysfunction and eventually to heart attacks and stroke (1).

Dr. Kilmer S. McCully, originally reported in 1969, that elevated homocysteine was associated with advanced atherosclerosis and premature death (2). 

He found that children born with a genetic disorder called homocystinuria, which causes the homocysteine levels to be very high, often died at a very young age with advanced atherosclerosis in their arteries. However, it was not until the 1990’s that the importance of homocysteine in heart disease and stroke was appreciated.

The Problems with Elevated Homocysteine:

Elevated homocysteine causes excessive clotting which diminishes blood flow to major regions of the body.  The lack of blood supply to the heart may cause heart attacks and the lack of blood supply to the brain accelerates the development of dementia and may lead to strokes (34).

High homocysteine is also associated with blood clots in other major regions of the body.  This includes the veins in such conditions as deep vein thrombosis and pulmonary embolism.  In some studies, even moderate levels of homocysteine levels showed higher rates of incidence of blood clot formation (56).

Elevated Homocysteine: 

Homocysteine is a metabolic byproduct of protein metabolism and in particular the metabolism of methionine.  Methionine is found in meats, seafood, dairy products, eggs, sesame seeds and Brazil nuts.

Homocysteine is metabolized through two pathways: remethylation and transsulfuration.  Remethylation requires folate and B12 coenzymes while transsulfuration requires pyridoxal-5-phosphate, the B6 coenzyme.

The Methylation Cycle and Homocysteine:

Typically, about 50% of homocysteine is remethylated and the remaining homocysteine is transsulfurated to cysteine.  The cysteine that is formed is then used to produce glutathione.  Glutathione is a powerful anti-oxidant that protects cellular components against oxidative stress.

Vitamin B2 and magnesium are involved in homocysteine metabolism.  Without proper levels of methylated B6, B12, folate, B2 and magnesium, dangerous levels of homocysteine may build up in the body (7).

Poor Diet and High Homocysteine:

A poor diet that is high in sugar and carbohydrates can deplete these key B vitamins and magnesium. If an individual has gut dysbiosis, they can have poor absorption of these key nutrients which can result in high homocysteine as well (8910).

Finally, genetic defects such as the MTHFR gene mutation can often cause problems with folate and B6 absorption and utilization are often found in individuals with elevated homocysteine (11).

Proper Supplementation:

Blood tests that show homocysteine levels above 9 umol/L are an indication of methylation deficiencies and elevated risk of cardiovascular disease. These individuals should supplement with pre-methylated forms of B vitamins such as methyl-folate, methyl-B12, Pyridoxal 5′ Phosphate, riboflavin, trimethylglycine, magnesium and choline.  

Clinically, I use a product called Homocysteine Support which has clinical doses of each of these nutrients and will lower homocysteine levels when the issue is do to B vitamin deficiencies.

Homocysteine Support

Homocysteine Support™ contains synergistic nutrients known to facilitate the efficient metabolism of homocysteine. Homocysteine Support™ maintains a healthy homocysteine pathway, allowing for the normal production of its necessary and important end products.

These include the sulfur-containing amino acids taurine and cysteine, and the neurotransmitters norepinephrine and dopamine.*

An optimally functioning homocysteine pathway provides methyl and sulfur groups for biochemical reactions such as detoxification, healthy immune function, ideal joint and cartilage structure, and brain and cardiovascular health.

When Does Dr Jockers Use This?

I use this product when I see elevated homocysteine over 9 umol/L in order to protect our brain and vascular tissue.  My team tests homocysteine on nearly all of our coaching clients and we highly recommend everyone test this biomarker at least one time per year. 

High homocysteine levels over 9 umol/L are associated with an increased risk of neuronal degeneration and cardiovascular events.  Providing the proper methylation support can help to reduce homocysteine into a safe level and improve neuronal and cardiovascular health. 

Normal Dosage:  Take 1 cap – 2x daily with or without food

Advanced Dosage:  Take 2 caps – 2x daily with or without food

***Warning:  Please consult your healthcare professional before using if you are pregnant, breastfeeding or considering use for a child.


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